15-keto Prostaglandin E2-前列腺素-ELISA_抗体_蛋白_核苷酸_试剂盒-深圳公海赌赌船官网登录网址科技有限公司

首页产品中心前列腺素

15-keto Prostaglandin E2

品牌：Cayman

官网链接

说明书

折扣/货期

货号：14720-1 mg	规格：1 mg	目录价：￥1694
货号：14720-10 mg	规格：10 mg	目录价：￥12376
货号：14720-5 mg	规格：5 mg	目录价：￥7070
货号：14720-500 µg	规格：500 µg	目录价：￥910

产品详情

产品名称:

15-keto Prostaglandin E2

别名:

15-keto PGE2|15-oxo PGE2

产品描述:

15-keto Prostaglandin E2 (15-keto PGE2) is a metabolite of PGE2 (Item No. 14010) formed by 15-hydroxy prostaglandin dehydrogenase (15-PGDH).{2777} Unlike PGE2, 15-keto PGE2 does not bind effectively to the PGE2 receptors EP2 and EP4 expressed in CHO cells (Kis = 2.6 and 15 µM, respectively) or induce adenylate cyclase activity in the same cells (EC50s = 1.8 and >33 µM, respectively). However, it does bind to EP2 and EP4 in HEK cells expressing these receptors (IC50s = 0.117 and 2.82 µM, respectively), as well as induces cAMP formation (EC50s = 0.137 and 0.426 µM, respectively) and the transcriptional activity of β-catenin/TCF in the same cells.{57866} 15-keto PGE2 inhibits CD3-CD28-MHC-I-induced proliferation of isolated human CD4+ T cells in a concentration-dependent manner.{57867} It also reduces mortality in a mouse model of LPS-induced sepsis when administered at a dose of 15 mg/kg.{57868}

保存温度:

-20

运输温度:

-20

预期分子量:

350.5

产品形式:

A crystalline solid

有效期:

1460

纯度:

≥98%