15-keto Prostaglandin E2-d9-前列腺素-ELISA_抗体_蛋白_核苷酸_试剂盒-深圳公海赌赌船官网登录网址科技有限公司

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15-keto Prostaglandin E2-d9

品牌：Cayman

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说明书

折扣/货期

货号：19350-100 µg	规格：100 µg	目录价：￥3024
货号：19350-50 µg	规格：50 µg	目录价：￥1694

产品详情

产品名称:

15-keto Prostaglandin E2-d9

别名:

15-keto PGE2-d9|15-oxo PGE2-d9

产品描述:

15-keto Prostaglandin E2-d9 (15-keto PGE2-d9) is intended for use as an internal standard for the quantification of 15-keto PGE2 (Item No. 14720) by GC- or LC-MS. 15-keto PGE2 is a metabolite of PGE2 (Item No. 14010) formed by 15-hydroxy prostaglandin dehydrogenase (15-PGDH).{2777} Unlike PGE2, 15-keto PGE2 does not bind effectively to the PGE2 receptors EP2 and EP4 expressed in CHO cells (Kis = 2.6 and 15 µM, respectively) or induce adenylate cyclase activity in the same cells (EC50s = 1.8 and >33 µM, respectively). However, it does bind to EP2 and EP4 in HEK cells expressing these receptors (IC50s = 0.117 and 2.82 µM, respectively), as well as induces cAMP formation (EC50s = 0.137 and 0.426 µM, respectively) and the transcriptional activity of β-catenin/TCF in the same cells.{57866} 15-keto PGE2 inhibits CD3-CD28-MHC-I-induced proliferation of isolated human CD4+ T cells in a concentration-dependent manner.{57867} It also reduces mortality in a mouse model of LPS-induced sepsis when administered at a dose of 15 mg/kg.{57868} a Kd = 1 nM for PGE2).{2777}

保存温度:

-20

运输温度:

-20

预期分子量:

359.5

产品形式:

A solution in methyl acetate

有效期:

730

纯度:

≥99% deuterated forms (d1-d9)