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17-phenyl trinor Prostaglandin F2α isopropyl ester

品牌：Cayman

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折扣/货期

货号：16824-1 mg	规格：1 mg	目录价：￥1022
货号：16824-10 mg	规格：10 mg	目录价：￥8050
货号：16824-5 mg	规格：5 mg	目录价：￥4536

产品详情

产品名称:

17-phenyl trinor Prostaglandin F2α isopropyl ester

别名:

17-phenyl trinor PGF2α isopropyl ester|17-phenyl trinor PGF2α-iPr|Bimatoprost isopropyl ester

产品描述:

17-phenyl trinor PGF2α N-ethyl amide is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name Bimatoprost.{8322} The N-ethyl amide prostaglandin prodrugs are converted to the active free acid more slowly than the analogous prostaglandin ester prodrugs such as latanoprost.{8941} This product is the isopropyl ester of the free acid prostaglandin which corresponds to Bimatoprost. The free acid, 17-phenyl trinor PGF2α, is a potent FP receptor agonist.{9206} In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity. The 17-phenyl trinor PGF2α isopropyl ester derivative was examined for IOP-lowering activity during the development of latanoprost.{9311} At the dose of 3 μg/eye in the monkey, 17-phenyl trinor PGF2α isopropyl ester was the most potent analog tested in reducing IOP, lowering the IOP 1.3 mm Hg below the level achieved by latanoprost. However, this derivative was also significantly more irritating to the eye than latanoprost.{9311}

保存温度:

-20

运输温度:

-20

预期分子量:

430.6

产品形式:

A solution in ethanol

有效期:

730

纯度:

≥98%