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17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F1α
货号:15895-1 mg 规格:1 mg 目录价:¥896
货号:15895-10 mg 规格:10 mg 目录价:¥6958
货号:15895-5 mg 规格:5 mg 目录价:¥3920
产品详情
产品名称:
17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F1α
别名:
17-TFM-PGF1α
产品描述:
A number of 17-aryl trinor and 16-aryloxy tetranor prostaglandin F2α derivatives have been approved for the treatment of glaucoma.{8941,9341,8839} These “ring” prostaglandin (PG) analogs have improved efficacy over the PGs with an n-alkyl lower side chain. Of these, the ones wherein the 13,14-double bond has been hydrogenated retain relatively good potency, but show a significantly reduced incidence of local irritant side effects.{9736} 17-trifluoromethylphenyl-13,14-dihydro trinor PGF1α (17-TFM-PGF1α) is a typical “ring” analog reminiscent of the trifluoromethyl-phenoxy ring of Travoprost. The a chain of 17-TFM-PGF1α is saturated, making this compound a formal member of the one-series PGs. Recent work has shown that in the “ring” series of analogs, this modification has little impact on FP receptor binding.{9668} As an ocular hypotensive agent, it is expected that 17-TFM-PGF1α would act very much like the free acid of latanoprost.
保存温度:
-20
运输温度:
-20
预期分子量:
460.5
产品形式:
A solution in methyl acetate
有效期:
365
纯度:
≥98%
CAS号:
1027401-98-4
分子式:
C24H35F3O5
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