BAY 57-1293-d4-其他-ELISA_抗体_蛋白_核苷酸_试剂盒-深圳公海赌赌船官网登录网址科技有限公司

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BAY 57-1293-d4

品牌：Cayman

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说明书

折扣/货期

货号：9004311-1 mg	规格：1 mg	目录价：￥3878
货号：9004311-500 µg	规格：500 µg	目录价：￥2156

产品详情

产品名称:

BAY 57-1293-d4

别名:

Pritelivir-d4

产品描述:

BAY 57-1293-d4 is intended for use as an internal standard for the quantification of BAY 57-1293 (Item No. 22129) by GC- or LC-MS. BAY 57-1293 is an orally bioavailable helicase-primase inhibitor.{39314} It inhibits the ATPase activity of herpes simplex virus (HSV) helicase-primase (IC50 = 30 nM). It inhibits HSV replication in Vero cells (IC50 = 20 nM for both HSV-1 and HSV-2) and is also active against porcine and bovine HSV strains (IC50s = 5 and 0.12 μM, respectively). In vivo, oral administration of BAY 57-1293 is effective against HSV-1 and HSV-2 in a lethal challenge model (ED50 = 0.5 mg/kg in mice and rats) and in a zosteriform spread model, at a dose of 15 mg/kg, in mice and Lewis rats.{39314,39315} It is also effective in a guinea pig model of genital herpes and a mouse model of ocular herpes. BAY 57-1293 reduces levels of amyloid-beta (Aβ) and phosphorylated Tau in HSV-1 infected Vero cells.{39316}

保存温度:

-20

运输温度:

-20

预期分子量:

406.5

产品形式:

A solid

有效期:

730

纯度:

≥99% deuterated forms (d1-d4)