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CD40L (human) (multimeric) (rec.) MultiPack
货号：AG-40B-0010-3010 规格：3 x 10 ug 目录价：￥7680
货号：AG-40B-0010-C010 规格：10 ug 目录价：￥3840
产品详情
产品名称:
CD40L (human) (multimeric) (rec.) MultiPack
别名:
MultimericCD40L™; ACRP30headless:CD40L; ACRP30headless:CD154; ACRP30headless:TNFSF5; ADIPOQ-CD40L
产品描述:
MultimericCD40L™ is a high activity construct in which two trimeric CD40 ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively simulates the natural membrane-assisted aggregation of CD40L in vivo. It provides a simple and equally potent alternative to [CD40L+enhancer] combinations. MultimericCD40L™ has shown to suppress alum-induced IL-1beta release and caspase-1 activation in a dose-, CD40- and time dependent manner, without affecting BMDM viability. It also effectively suppressed the inflammasome function triggered by NLRP3 activators. The secretion of caspase-1 independent inflammatory mediators has been shown to be unaltered or even enhanced.
宿主来源:
CHO cells
靶标/特异性:
Binds to human CD40.
产品浓度:
0.1mg/ml after reconstitution
保存温度:
-20°C
运输温度:
BLUE ICE
预期分子量:
~35-40kDa (SDS-PAGE)
产品形式:
solid
存储溶液:
Lyophilized. Contains PBS
有效期:
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
纯度:
>95% (SDS-PAGE)
生物活性:
Induces B cells activation (as demonstrated by dose-dependent upregulation of CD86) (ED50: <1ng/ml). B cell expansion online protocol available.
内毒素水平:
<0.01EU/µg purified protein (LAL test, Lonza).
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