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Autophagy in human health and diseases
Autophagy contributes to basal physiological homeostasis by regenerating metabolic precursors and clearing subcellular debris. Deregulation of this process has been implicated in many diseases, including cancer, metabolic and neuro degenerative disorders, and cardiovascular and pulmonary diseases. Shown above, the diagram reports the publication trends for the study of autophagy. However, clinical targeting of autophagy in human diseases is limited due to an obscure of how autophagy contributes to pathogenesis. Exploration of the mechanisms underlying this autophagy process may lead to the identification of new targets for clinical utility.
Please find the list below for a collection of autophagy molecules associated with human diseases.
For a complete catalogs of autophagy antibodies from GeneTex, visit our website at
http://www.genetex.com/Web/News/Autophagy-332
Gene | Antibody | Association |
BECN1 | Beclin 1 antibody (GTX113039) | Breast, ovarian, and prostate cancers |
UVRAG | UVRAG antibody (GTX129111) | Colon cancers |
ATG1 | ULK1 antibody (GTX128064) | Major autophagy initiator |
ATG9 | ATG9A antibody (GTX128427) | Assists in autophagosomal assembly |
ATG5 | ATG5 antibody (GTX113309) | Systemic lupus erythematosus, asthma, and lung dysfunction |
ATG16L1 | ATG16L1 antibody (GTX129098) | Chrohn's disease |
NOD2 | NOD2 antibody (GTX30694) | Chrohn's disease, and mycobacterium leprae infection |
IRGM | IRGM antibody (GTX85038) | Chrohn's disease, and M. tuberculosis infection |
LAMP2 | LAMP2 antibody (GTX103214) | Danon's cardiomyopathy |
PARK2 | Parkin antibody (GTX25667) | Parkinson's disease, colon, lung and breast cancers |
SQSTM1 | SQSTM1 antibody (GTX100685) | Paget's disease |
SMURF1 | SMURF1 antibody (GTX89472) | Ulcerative colitis |
Reference
N Engl J Med. 2013 Feb 14;368(7):651-62
