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EndoG antibody [7G1G10]
货号：GTX84987 规格：100μg 目录价：￥6400
产品详情
产品名称:
EndoG antibody [7G1G10]
别名:
endonuclease G
反应种属:
Human, Rat
宿主来源:
Mouse
实验应用:
ELISA, WB
同种型:
IgG1
免疫原:
Recombinant protein corresponding to amino acids 51 - 140 of human EndoG.
克隆性:
Monoclonal
克隆号:
7G1G10
纯化方式:
Purified by affinity chromatography
偶联:
Unconjugated
产品浓度:
1 mg/ml (Please refer to the vial label for the specific concentration.)
阳性对照:
HepG2 Cell Lysate(GTX27900) , EndoG Recombinant Protein(GTX48208-PRO)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
预期分子量:
33
产品形式:
Liquid
存储溶液:
PBS, 0.02% Sodium azide.
产地:
美国
功能与背景:
The fragmentation of nuclear DNA is a hallmark of apoptotic cell death. The activities of caspase and nuclease are involved in the DNA fragmentation. Caspase-activated deoxyribonuclease (CAD), also termed DNA fragmentation factor (DFF40), is one such nuclease, and is capable of inducing DNA fragmentation and chromatin condensation after cleavage by caspase-3 of its inhibitor ICAD/DFF45. Caspase and CAD independent DNA fragmentation also exists. Recent studies demonstrated that another nuclease, endonuclease G (EndoG), is specifically activated by apoptotic stimuli and is able to induce nucleosomal fragmentation of DNA independently of caspase and DFF/CAD. EndoG is a mitochondrion-specific nuclease that translocates to the nucleus and cleaves chromatin DNA during apoptosis. The homologue of mammalian EndoG is the first mitochondrial protein identified to be involved in apoptosis in C. elegans. EndoG also cleaves DNA in vitro.
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