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折扣/货期| 货号：CDX-M0565-M010 | 规格：10 mg | 目录价：￥2828 |
| 货号：CDX-M0565-M050 | 规格：50 mg | 目录价：￥6202 |
产品详情
产品名称:
MK-4827 tosylate
别名:
Niraparib tosylate; (S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide 4 methylbenzenesulfonate
产品描述:
MK-4827 is an orally bioavailable inhibitor of poly(ADP-ribose) polymerase 1 (PARP1) and PARP2 (IC50s=3.8 and 2.1nM, respectively). It inhibits the proliferation of cancer cells carrying the breast cancer mutations BRCA1 and BRCA2 in vitro and has efficacy alone against a xenograft of BRCA1-deficient cancer in mice. MK-4827 sensitizes human lung and breast cancer xenografts to radiation in mice.3 Formulations containing MK-4827 are effective against ovarian cancer.
宿主来源:
Synthetic
保存温度:
-20°C
运输温度:
Ambient
预期分子量:
492.6
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at -20°C.
产地:
瑞士
纯度:
>99% (HPLC)
CAS号:
1038915-73-9
分子式:
C19H20N4O . C7H8O3S
溶解度:
Soluble in DMSO or DMF (both 20mg/ml). Sparingly soluble in ethanol (1mg/ml) or water (<1mg/ml).
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