Olaparib-抑制剂-ELISA_抗体_蛋白_核苷酸_试剂盒-深圳公海赌赌船官网登录网址科技有限公司

首页产品中心抑制剂

Olaparib

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：CDX-O0144-M100	规格：100 mg	目录价：￥1414
货号：CDX-O0144-G001	规格：1 g	目录价：￥6202

产品详情

产品名称:

Olaparib

别名:

AZD 2281; Ku-0059436; Lynparza; 1-(Cyclopropylcarbonyl)-4-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluorobenzoyl]piperazine

产品描述:

Olaparib is a cell-permable potent inhibitor of PARP1 and PARP2 (IC50=5 and 1nM, respectively) but is less effective against the PARP tankyrase-1 (IC50=1.5µM). Some poly(ADP-ribose) polymerases (PARPs) assist in the repair of single-strand DNA nicks, an important step in base excision repair (BER), counteracting against DNA alkylating agents. Olaparib is a anticancer and chemotherapeutic agent (especially in cancers with BRCA mutations) that can be used in cells and in animals, alone or in combination therapy with alkylating agents, to block BER and increase cancer cell death.

宿主来源:

Synthetic

保存温度:

-20°C

运输温度:

Ambient

预期分子量:

434.47

产品形式:

solid

有效期:

Stable for at least 2 years after receipt when stored at -20°C.