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Telaprevir

品牌：Adipogen

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说明书

折扣/货期

货号：AG-CR1-3741-M010	规格：10 mg	目录价：￥1080
货号：AG-CR1-3741-M050	规格：50 mg	目录价：￥3240
货号：AG-CR1-3741-M250	规格：250 mg	目录价：￥8280

产品详情

产品名称:

Telaprevir

别名:

VX-950; LY570310; MP-424

产品描述:

The antiviral agent telaprevir is a covalent, reversible inhibitor of hepatitis C virus (HCV) nonstructural protease 3/4A (NS3/4A; Ki = 7nM), a serine protease that is essential for viral replication by cleaving the virally encoded polyprotein into mature proteins like NS4A, NS4B, NS5A and NS5B, leading to inhibition of viral polyprotein processing and subsequently decrease of viral RNA replication. It inhibits viral replication in genotype 1b HCV replicon cells (IC50 = 354nM) and isolated human fetal hepatocytes infected with genotype 1a HCV-positive patient sera (IC50 = 280nM). Used in stabilizable polypeptide linkages (StaPLs) chemogenetic platform, for pharmacological regulation of protein expression/function. StaPL sequences can be engineered into target proteins rendering them functional only in the presence of telaprevir. Telaprevir has been identified as a potential inhibitor of SARS-CoV-2, responsible for COVID-19. It inhibits SARS-CoV-2 viral replication by targeting the viral 3C-like Protease (3CLpro), interacting through hydrogen bond formation with Ser46 and Gln182 main chain amines as well as Glu166 alpha-carboxyl group.

保存温度:

-20°C

运输温度:

Ambient

预期分子量:

679.9

产品形式:

solid

有效期:

Stable for at least 2 years after receipt when stored at -20°C.

产地:

瑞士