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折扣/货期| 货号：CDX-T0460-M010 | 规格：10 mg | 目录价：￥434 |
| 货号：CDX-T0460-M050 | 规格：50 mg | 目录价：￥1330 |
产品详情
产品名称:
Telmisartan
别名:
BIBR 277; Micardis; Pritor; 4'[(1,4'-Dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl][1,1'-biphenyl]-2-carboxylic acid
产品描述:
Telmisartan is a nonpeptide angiotensin II receptor antagonist which selectively inhibits the angiotensin II AT1 receptor subtype (Ki=3.7nM). Telmisartan exhibits antihypertensive activity in a renin-dependent model of hypertension. In addition to blocking the renin-angiotensin system (RAS), telmisartan acts as a selective modulator of peroxisome proliferator-activated receptor gamma (PPAR-gamma), a central regulator of insulin and glucose metabolism and improving insulin sensitivity. It is believed that telmisartan's dual mode of action may provide protective benefits against the vascular and renal damage caused by diabetes and cardiovascular disease (CVD). Through these actions, telmisartan potently reduces blood pressure in various animal models of hypertension, diminishing cardiac hypertrophy, cardiovascular and renal risk and glomerulosclerosis. Furthermore, telmisartan inhibits proliferation in several cancer models by inducing apoptosis and cell cycle arrest.
宿主来源:
Synthetic
保存温度:
+20°C
运输温度:
Ambient
预期分子量:
514.62
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at RT.
产地:
瑞士
纯度:
>98% (HPLC)
CAS号:
144701-48-4
分子式:
C33H30N4O2
溶解度:
Soluble in DMSO, chloroform, DMF or ethanol.
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