官网链接
折扣/货期| 货号：GTX500022 | 规格：1pair | 目录价：￥4700 |
产品详情
产品名称:
Von Hippel Lindau ELISA Pair
别名:
Von Hippel-Lindau Tumor Suppressor , Hrca1 , Rca1 , Vhl1 , Pvhl , Vhl
反应种属:
Human
实验应用:
ELISA, Sandwich ELISA
克隆号:
产品浓度:
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
-20°C
产品形式:
Liquid
产地:
美国
功能与背景:
Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq]
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